The research team identifies the metabolic footprint associated with perception of satiety

The results of the European SATIN (SATiety INnovation) study revealed an association between certain metabolites in blood and the observed satiety after eating.

Regulating satiety is an important factor that determines an increase or decrease in energy intake and, therefore, has a significant impact on the development and / or development of obesity. The team consists of researchers Lucia Camacho Barcia, Jesus Garcia Gavilan, Christopher Papandreou and Monica Polo, who lead the Research Group in Nutrition and Metabolic Diseases in the Department of Biochemistry and Biotechnology (University of Rovira e Virgili – Tarragona – Spain). She worked with researchers from Denmark and the United Kingdom to identify a group of metabolites in the blood that are associated with greater perception of satiety after eating.

The study, conducted on 140 overweight and obese volunteers, showed that higher concentrations of glycine and linoleic acid were associated with a greater sense of satiety, while sucrose and some types of sphingomyelin (C32: 2, C38: 1) had a negative effect. Associated (i.e. with a lower perception of satiety). Although the metabolites are widely used in nutrition research, this is the first time that they have been used to study the perception of satiety. These results not only contribute to designing possible strategies to measure satiety more objectively than usual methods but also to a better understanding of the metabolic pathways involved in satiety regulation which may lead in the future to a useful tool for designing more effective strategies for appetite control and body weight.

This research is part of a larger study (SATIN – SATiety INnovation) conducted to assess the extent to which satiety regulation contributes to body weight control in the medium term. The results have been published elsewhere. A recently published study focuses on the metabolic aspects of regulating hunger and satiety. Analyzes were performed using data collected from satiety tests. To this end, 151 volunteers from Satin’s study went to recruitment centers after fasting. Once they arrived, they were given a controlled breakfast and satiety data were collected for the next two hours. The volunteers were also given lunch while they were in the building and given an evening meal to take away so that the researchers could control the data about the food they ate throughout the day. Satiety tests were performed on several occasions during the study.

By identifying which substances make it possible to predict satiety, more customized nutrition programs can be implemented and products can be designed to control hunger and satiety by increasing or decreasing the concentration of these metabolites in the blood.


Reference: Camacho-Barcia L, García-Gavilán J, Papandreou C, Hansen TT, Harrold JA, Finlayson G, Blundell JE, Sjödin A, Halford JCG, Bulló M. Mainstream “Metabolites Associated with Postprandial Satiety in Overweight / Obese Participants: Satin Study “. Nutrients. 2021 Feb 8; 13 (2): 549. doi: 10.3390 / no 13020549. PMID: 33567505.

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