Researchers demonstrate how depletion of stem cells leads to recurrent pregnancy loss

Durham, North Carolina – Depletion of a specific type of stem cell in the endometrium during pregnancy may be a significant factor behind a miscarriage, according to a study released today in Stem Cells. The study, conducted by researchers at Warwick Medical School, University of Warwick, Coventry, England, indicates that recurrent pregnancy loss is a result of the loss of precipitant cells preceding pregnancy.

“This raises the possibility that it can be harnessed to prevent pregnancy disorders,” said corresponding author Jan J. Brosens, MD, professor of obstetrics and gynecology at Warwick Medical School (WMS).

The endometrium – or endometrium – is a highly regenerative tissue that is capable of adopting various physiological states during childbearing years. In the second half of the menstrual cycle when progesterone levels are high, the endometrium begins to be remodeled more intensively, heralding the start of a short period during which the embryo can be implanted. Pregnancy depends on this transformation, a process called the decidua, because it is driven by the differentiation of endometrial cells into specialized decidual cells. These cells transfer the necessary plasticity to the tissues to accommodate the rapid growth of the fetus.

“While the magnitude of tissue remodeling required for conception makes it likely that balanced progenitors and highly proliferating proliferating progenitor cells are critical in forming a strong maternal-fetal interface, the mechanisms underlying this are unclear,” said Dr. Prosins.

The same team recently described the presence of a separate group of highly proliferating stromal cells (hPMC) during the implantation window. Stem / mesenchymal stem cells can be isolated from bone marrow, fat, and other tissue sources, and they can differentiate into a variety of cell types depending on the culture conditions in which they are grown. In this latest study, the research team set out to characterize hPMCs.

“Our findings indicate that hPMC is derived from stem cells derived from bone marrow and recruited into the endometrium at the time of the embryo implantation. These cells appear crucial in pregnancy to accommodate the rapid growth of the placenta.” Dr Bruinsens said. “We also found that these rare but highly specialized cells were depleted in the endometrium in women with repeated pregnancies.”

Siobhan Quinby, MD, FRCOG, Professor of Obstetrics and Honorary Counsel at Coventry University Hospitals, Warwickshire and University of Warwick, was part of the research team. “These are very exciting results,” she said. We have already demonstrated that we can augment these highly proliferating cells in the endometrium before pregnancy. These new findings explain why these highly proliferating cells are so important to prevent miscarriage and possibly spontaneous preterm labor, two devastating pregnancy disorders that affect so many women and couples around the world.

Dr.. Yan Nolta, Editor-in-Chief of the magazine Stem Cells“This flagship study begins to find answers to a very worrying problem in pregnancy disorders and gives insight into understanding the factors that can contribute to pregnancy loss. We are very excited to be able to publish these important findings,” he said.

The study involved the recruitment of women attending the Tommy National Center for Abortion Research at Coventry University Hospital and Warwickshire National Health Service in England, with support from the Wellcome Trust.


The full article, “Characterization of highly proliferating progenitor cells during implantation window in human endometriosis” can be accessed at magazines.on the Internet.Wiley.Com /Doi /stomach muscles /10.1002 /Stems.3367.

About the magazine: Stem Cells, A peer-reviewed journal published monthly that provides a forum for the immediate publication of original investigative research and summary reviews. The journal covers all aspects of stem cells: embryonic stem cells / pluripotent stem cells. Tissue-specific stem cells; Cancer stem cells the niche of stem cells the epigenetics of stem cells, genomics and proteomics; And localized and clinical research. Stem Cells It is jointly published by AlphaMed Press and Wiley.

About AlphaMed Press: Founded in 1983, AlphaMed Press with offices in Durham, North Carolina, San Francisco, California, and Belfast, Northern Ireland, publishes three world-famous peer-reviewed magazines with globally recognized editorial boards dedicated to advancing the knowledge and education in their focus . Majors. Stem Cells® is the first magazine in the world dedicated to this fast-paced field of research. Oncologist® Dedicated to oncologists, clinicians in the community and hospital charged with caring for cancer patients. Stem Cells Translated Medicine® Dedicated to advancing significantly the clinical use of both molecular and cellular biology of stem cells. By connecting stem cell research and clinical trials, SCTM will help move the applications of these important investigations closer to accepted best practices.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scientific journals, along with our solutions for digital learning, assessment and certification, help universities, scientific societies, companies, governments, and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our shareholders. The company’s website can be reached at http: // www.Wiley.Com.

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