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Monash University leads a breakthrough against antibiotic resistance

Scientists have investigated the phages that can kill the world’s leading superbugs, Acinetobacter baumannii, responsible for up to 20% of infections in intensive care units.

A major risk of hospitalization is a bacterial infection.

Hospitals, especially areas that include intensive care units and surgical wards, are teeming with bacteria, some of which are resistant to antibiotics – they are known as “superbugs.”

Treating superbugs is difficult and expensive, and can often have direct consequences for the patient.

Now, new research published today in the prestigious journal Nature Microbiology has discovered how antibiotic resistance can be reversed in one of the most dangerous bacteria.

The strategy involves using phages (also known as phages).

“Phages are viruses, but they cannot harm humans,” said Dr. Fernando Gordillo Altamirano, the lead researcher on the study, from Monash University’s School of Biological Sciences.

“They only kill bacteria.”

The research team investigated the phages that can kill the world’s leading superbugs. Stagnant BomaniaIt is responsible for up to 20 percent of injuries in intensive care units.

“We have a large group of phages that are capable of killing antibiotic resistance A. baumanniiSaid Dr. Jeremy Barr, senior study author and group leader in the School of Biological Sciences and part of the AMR Impact Center.

“But these superbugs are smart, and in the same way they become resistant to antibiotics, they also quickly become resistant to our sterilants,” said Dr. Barr.

The study determines how the superbugs become resistant to attack from the phages, thereby losing the antibiotic resistance.

To. The Albomani produces a capsule, which is a sticky, sticky outer layer that protects it and stops antibiotics from entering.

“Our phages use the same capsule as their port of entry to infect the bacterial cell.

“In an attempt to escape phages, A. baumannii It stops producing its capsule; Then we can hit her with the antibiotics that were fighting her. “

The study showed sensitivity to at least seven different antibiotics.

“This greatly expands the resources for treatment A. baumannii Dr. Bar said.

“We are making this super virus less scary.”

Although more research is needed before this treatment strategy can be implemented in the clinic, the outlook is encouraging.

“Infertility had excellent effects in experiments using mice, so we are excited to continue working on this approach,” said Dr. Gordillo Altamirano.

“We are showing that bacteriophages and antibiotics can work great as a team.”

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Media contact
Silvia Drupolich
[email protected]http: // dx.Resonate.Deer /10.1038 /s41564-020-00830-7

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