First-degree relatives with kidney disease triple the risk of disease

In a large population-based family study, a family history of kidney disease was closely related to an increased risk of developing chronic kidney disease.

In this large population-based family study recently published in American Journal of Nephrology, Researchers investigated the familial clustering of CKD by comparing the risk of developing chronic kidney disease (CKD) in affected first degree individuals compared to the general population. It was noted that participants with an affected first-degree relative had a three times higher risk of developing CKD than the general population, regardless of BMI, high blood pressure, diabetes, hypercholesterolemia, history of cardiovascular disease (CVD), and the condition Smoking The authors of this study noted a 1.56-fold higher risk in those with an affected pair, indicating that co-environmental factors and / or heterogeneity play a role. Inheritance of eGFR was significant (44%), while heritability in UAE was moderate (20%). The inheritance of markers associated with the kidneys and electrolytes in the blood ranged between 20 and 50%. These results indicate an important role for genetic factors in modifying susceptibility to kidney disease in the general population.


Article: Familial clustering of chronic kidney disease and inheritance of kidney biomarkers in the general population: a life line group study

Authors: Jia Zhang, PhD, Chris HL Theo, PhD, Ron T. Gansevort, MD, PhD, Harold Snyder, PhD

DOI: https: //Resonate.Deer /10.1053 /J.I find.2020.Eleven.012

Media contact
Julie Kembrah
[email protected]http: // dx.Resonate.Deer /10.1053 /J.I find.2020.Eleven.012

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