Bluetooth Mouse – You can read the mind of the mouse wirelessly

A lightweight, compact, wireless Bluetooth Low Energy Neural Recording System for Mice

Credit: Copyright (C) TOYOHASHI University of Technology. All rights reserved.


A research team in the Department of Electrical and Electronic Information Engineering, Department of Computer Science and Engineering, Department of Applied Chemistry and Life Sciences, and the Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) at Toyohashi University of Technology have developed a compact and lightweight, wireless neural recording system based on Bluetooth Low Energy technology for use in mice. The wireless system weighs 3 with battery, and has the advantages of high signal quality, good versatility and low cost, compared to wired recording with a commercial neurophysiology system. The study was published online at B: Sensors and actuators: chemicalOn January 8, 2021.


Electrophysiological recording, which uses small-scale needle-like electrodes that are penetrated into brain tissue, has made a significant contribution to neuroscience and basic medicine applications. However, electrophysiology recording requires improvements in signal quality, invasion, and the use of cables. Although wireless recording can meet these requirements, conventional wireless systems are heavy and bulky for use in small animals such as mice, and systems based on their ad hoc technologies are expensive and lack versatility.

The research team developed a lightweight, compact, and low-energy wireless neural recording system with Bluetooth technology. As explained by the first author of the article PhD. Candidate Shinnosuke Idogawa, “We have dealt with the challenge of developing a lightweight and compact wireless neural recording system for use in mice developed in the size of 15 x 15 x 12 mm.3 The system weighed 3.9 grams with the battery, which is less than 15% of the mouse’s weight (eg, 33 grams for a two-week-old C57BL / 6 mouse). Surprisingly, the wireless system demonstrates advantages not only for recording without the use of any cables, but also improvements in signal quality, including signal-to-noise ratios, compared to wired recording using a commercial neurophysiological system. In addition to these benefits, the upgraded wireless system costs $ 79.90, which is less than the wired system.

Developmental background:

Head of the research team, Associate Professor Takeshi Kawano said, “We demonstrated the wireless single-channel recording system as our first step, but we can increase the number of channels based on our system, and we are currently working on developing wireless systems for four channels and more. The device’s features will help us develop small wireless neurophysiological systems with good versatility and low cost for a wide range of users. “

a future vision:

The research team believes that the wireless recording system could also be used to study behavioral characteristics of mice as well as screen drugs with mice. Due to its light weight, compactness and Bluetooth technology, the upgraded wireless neural recording system can also be used with other species, including mice and monkeys.


Funding Agency:

This work was supported by JSPS KAKENHI (grant numbers 17H03250, 26709024 and 20H00244), the strategic progression of NEDO’s multipurpose robot and artificial intelligence technologies program, Nagai Foundation for Science and Technology. RN is supported by Takeda Science Foundation. KK is supported by JSPS KAKENHI (Grant Number 15H05917).


Shinnosuke Idogawa, Koji Yamashita, Rioki Sanda, Rika Numano, Kowa Koida, and Takeshi Kawano (2021). Lightweight, Wireless Bluetooth Low Energy Neural Recording System for Mice, B: Sensors and actuators: chemical, 10.1016 / j.snb.2020.129423.

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