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Best Protein Science Papers of 2020

The 2020 Protein Science Best Paper award winners are Yu-Ting Huang from Chung Hsing National University in Taiwan, and Samuel Junod and Joseph Kelich from Temple University, USA.

Winners of 2020 Protein science Best Paper Prizes are Yu-Ting Huang from National Chung Hsing University in Taiwan, and Samuel Junod and Joseph Kelich from Temple University, USA.

Dr Huang, who works in the Pei-Fen Liu Laboratory, made an unexpected discovery that ATP could alter the foldability and function of human proteins by destabilizing the protein. The metabolic environment of the cancer cell.

As Yu Ting explains, she wanted to be either a doctor, a scientist, or a medical specialist. “Although I could not get into medical school, I met Dr. Bai-Fen Liu when I was a graduate student at National Chung Hsing University. He gave me an opportunity to come close to my dream. Nowadays, people are paying more and more attention to their health, especially In these two years it couldn’t be better if what we find in this research can help solve the problem of drug resistance, and contribute to the medical fields. At the moment, I am teaching chemistry and science to teenagers. I hope these kids will be inspired and become pioneers in circles. The academy. “

Pei-Fen Liu pays tribute to the skill and determination that Yu-Ting brought to the project. Yu-Ting is an eminent and self-motivated young scientist in protein science. I originally joined my lab with limited basic knowledge about protein folding. Surprisingly, she picked up most of the concepts and learned the basic experiences quickly. And her problem-solving and logical reasoning exceed the standards of other students. We initially experienced protein purification and sample preparation in this project for a human protein uridine phosphorylase I. I was able to overcome all obstacles step by step. Continuously, it devised a new experimental design to study the interaction between ATP and the partially unfolded state of this protein. Then an interesting model was developed to explain the relationship between protein concentration and the effect of crosslinking. It is a pleasure to work with her in exploring unknown topics. I think she is on her way to achieving success in her career path. “

The other Best Paper award winners, Samuel Gounod and Joseph Keelis, were honored for their study on the nuclear cellular transport of intrinsically perturbed proteins. 2 Using high-resolution high-resolution microscopy in the Weidong Yang Laboratory, they were able to measure the kinetic transport and 3D spatial locations of transport methods across the pore complexes. Nucleus of various intrinsically disturbed proteins. They found that the folded proteins’ implementing roles are not followed by the disordered roles. For the latter, diffusion efficiencies and methods are determined by the ratio of their charged and hydrophobic amino acid content.

As Dr. Keelis explains, “I am currently a postdoctoral researcher at the Westar Institute in Philadelphia, studying the role of telomere protein defects in cancer. The project for which I was awarded this award was carried out while I was studying for my PhD in the Weidong Yang Laboratory. I would also like to point out that Samuel Junod and I put together an amazing team for this project and Yang Lab provided an amazing multidisciplinary team-based approach to science that I love. ”

Sam also identifies his own background. “I started my research work during my undergraduate studies under the supervision of Dr. Weidong Yang. With the guidance of Dr. Yang, I resolved the spatial location of many nuclear-pore complex scaffold proteins (NPC) using nanopore labeling and single-molecule microscopy. Because NPC is a pathway. As a major for proteins entering and exiting the nucleus, the mapping of the scaffold proteins site gave insight into the structural makeup of the important cellular complex.After a short departure to the private sector as a chemist, I returned to Temple University to pursue a PhD and continue my research on the NPC with Dr. Weidong Yang. Currently, I have expanded my research on nucleoproteins to include the effect of disruptive nucleopurins (Nups), characterized by the presence of repeat phenylalanine glycine (FG), on the transport of nuclear proteins. I am very fortunate to study under the direction of Dr. Weidong Yang and to collaborate on several projects with Dr. Joseph Kellish I look forward to applying my knowledge of NPC microscopy and single-molecule microscopy to other biological questions. ”

As Dr. Yang explains, Sam and Jo were an amazing team. “Samuel Gounod joined my lab first as an undergraduate student in 2014, then a masters student in 2017. Based on his outstanding performance in research, I recommended him to the Graduate Committee for his acceptance as a PhD candidate in our department in 2018. Joseph Keles is one of the best students PhD in my lab.He graduated from my lab in 2018 and is currently a postdoctoral fellow at the Wistar Institute in Upenn. Sam and Joe have formed a good team to work on several projects including nucleocytoplasmic transfer of IDPs. In the IDP project, they overcame the challenges of purification and classification “They have also gone to great lengths to learn single-molecule and ultrafine microscopy techniques before they successfully tracked individual IDPs to navigate native nuclear pores with these advanced methods.”

On behalf of the Protein science And the Protein Society, congratulations to these talented young scientists for their outstanding achievements. The winners will be honored at the 35th Anniversary Seminar that will be held roughly July 7-9 and July 12-14, 2021. The online meeting will feature over 50 speakers, including member entries and contributions to talks, Protein Association Awards, and presentations. Live posters, thematic workshops on important topics such as diversity, inclusion and networking opportunities.

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References

1. Huang YT, Yeh PC, Lan SC, Liu PF. Metabolites modulate the functional state of human uridine 1 phosphorylase. Protein Sciences. 2020; 29: 2189-2200.

2. Junod SL, Kelich JM, Ma J, Yang W. Cellular nuclear transfer of intrinsically perturbed protein studies by ultrafast high-resolution microscopy. Protein Sciences. 2020; 29: 1459-1472.

Protein scienceEdited by Brian W. Matthews, it is a premier forum for publishing and discussing groundbreaking research into protein structure, function, design, and emerging applications. All manuscripts submitted for “Best Paper” awards that will be announced in the year following their publication will be considered. These awards aim to honor the exemplary work of early authors or other early-career contributors to selected essays and mark the continuation of The Protein Society’s long-standing commitment to supporting the next generation of protein scientists.

The Protein Society is a leading international association dedicated to promoting research and development in protein science. Founded in 1986, the purpose of the association is to provide international forums to facilitate communication, collaboration and collaboration regarding all aspects of the study of proteins. In support of these goals, the association publishes Protein science, The premier journal in the field, to host an annual international symposium, and facilitate the education of early-career protein scientists across all areas of the discipline. The Protein Society members represent a wide range of academic, industrial, governmental and not-for-profit institutions from more than 50 countries around the world. Media inquiries can be directed to Raluca Cadar, CEO, at 844.377.6834.

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