Credit: Marshall Marbuti / Roman Coszol
The balance of the human gut flora, which is made up of hundreds of bacterial species and phages (bacterial viruses), is critical to good health. A research team, including scientists from CNRS * and the Pasteur Institute, distinguished bacterial and phage interaction networks of microbes in ten healthy individuals, with unprecedented precision. Scientists have discovered several hundreds of bacterial and phage genomes and identified thousands of interactions connecting them by measuring the connections between virus DNA molecules and their hosts. This method has the advantage of providing comprehensive data from limited biological samples. The results were then analyzed using algorithms similar to those applied in studying social media communities. This panoramic view of the bacteria-phage relationships can be applied to treatments that include intestinal flora, such as stool transplants and swallowing therapy. The approach used in the study, recently published in eLife, It could also lead to more accurate analyzes of terrestrial and marine ecosystems.
* Researchers from the Génétique des Génomes Unit (CNRS / Institut Pasteur) and the Center for Bioinformatics and Biostatistics (CNRS / Institut Pasteur)
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