Four group investments will focus on cancers of the head and neck related to Fanconi anemia and HPV
(New York) January 21, 2021 Stand Up To Cancer® (SU2C) today announced $ 3.25 million in grants from four national nonprofits to fund research to find new treatments for head and neck cancer, which are newly diagnosed in about 65,000 Americans each year.
The grants include contributions of $ 1.5 million each from the Fanconi Anemia Research Fund and the Farrah Fawcett Foundation. The American Head and Neck Association and the Head and Neck Cancer Alliance are each providing $ 125,000 to support the project.
The grants will support new approaches to treating cancers of the head and neck, especially those associated with Fanconi anemia, HPV, or HPV. Fanconi anemia is a rare inherited disease that often leads to bone marrow failure and cancer. The incidence of squamous cell carcinoma of the head and neck in people with Fanconi anemia is 500 to 700 times that of the general population, and treatment options are limited. HPV is a very common virus that can cause cancer, including throat cancer. Approximately 45,300 people with HPV will receive a cancer diagnosis each year in the United States
Head and neck cancers associated with Fanconi anemia or HPV have one thing in common: the genetic defects that cause Fanconi anemia, as well as the genetic changes caused by HPV infection, both of which negatively affect the DNA repair systems, which may lead to infection. With cancer.
“These grants will collectively benefit people with Fanconi anemia and their families in a meaningful and impactful way,” said Mark Quinlan, executive director of the Fanconi Anemia Research Fund, which funds research on the disease and provides support services to those affected by Fanconi anemia. “We are excited to join other funders and Standing Against Cancer is part of this project, which will facilitate collaboration between experts from various fields to help address some of the biggest challenges associated with head and neck cancer.
“The investment we make today will ultimately make a difference to the tens of thousands of people diagnosed with head and neck cancer each year,” said Alana Stewart, president and CEO of the Farrah Fawcett Foundation, which funds research. Cancers associated with human papillomavirus. Human papillomavirus is responsible for 5% of cancer cases worldwide. Since we believe that the mechanism of cancer development by HPV may be similar in different disease sites, we feel that this team will have a major impact on our mission. We are pleased to be a part of this important work. “
“Bringing together this group of donors provides a unique opportunity to unite researchers who typically take different approaches to understanding the underlying molecular mechanisms that lead to different forms of head and neck cancer,” said Lee Helman, director and deputy director of the Osteosarcoma Institute. Chairman of the SU2C Scientific Advisory Committee. Dr. Hillman will lead the Joint Scientific Advisory Committee of the Head and Neck Cancer Research Team. This is the kind of collaboration that Stand Up to Cancer fosters and it is fascinating to see how this model leads to new ways of addressing questions in cancer biology and treatment.
Head and neck cancers can appear in the nasal cavity, sinuses, lips, mouth, salivary glands, thyroid gland, and throat or larynx. Experts estimate that there are about 550,000 cases of different types of head and neck cancer diagnosed worldwide every year, with 300,000 deaths annually from cancers. About 65,000 new cases, excluding thyroid cancer, are diagnosed in the United States each year. Research has also shown that the incidence of head and neck cancer increases in blacks and that the 5-year survival rate for black people is lower compared to white people. Black patients are usually diagnosed with more advanced head and neck cancer.
Across all races and ethnicities, men have higher rates of oropharyngeal carcinomas associated with HPV (back of the throat, including the base of the tongue and tonsils) than women. Hispanic men and women have lower rates of HPV-associated oral and pharyngeal cancers compared to white and non-Hispanic men and women. In addition to oral and pharyngeal cancers, HPV can also cause cancers of the anus, cervix, penis, vagina, and vulva.
“There is a lot of work that needs to be done to make progress in treating head and neck cancer,” said Christina Kassendorf, executive director of the American Head and Neck Association, which works to encourage research and better treatment of head and neck cancer. “We know funding great scientists who can focus on doing groundbreaking work will make a difference.”
“Mouth, head and neck cancers are the sixth most common type of cancer in the world,” said Amanda Hollinger, Executive Director of the Head and Neck Cancer Association. We need to find better ways to diagnose and treat these cancers. That is why we are excited to be a part of this cooperation. “
The research team will be called “Stand Up To Cancer-Fanconi Anemia Research Fund – Farrah Fawcett” The Chair Of The Farrah Fawcett Foundation And The Cervical Cancer Research Team The researchers will be brought together in an innovative way. After requesting applications, scientists will be selected to attend the Idea Lab for two days, scheduled for early 2021. The Idea Lab will be organized to help leading scientists from various disciplines explore how they can work together to advance the understanding of head and neck cancers. At the end of the meeting, researchers will be invited to write formal proposals and propose a budget for a three-year grant.
The Stand Up To Cancer Foundation has issued an application submission; Interested researchers must apply, by March 22, 2021, to participate in the Idea Lab. Scientists from all fields of oncology are encouraged, along with biology, engineering, chemistry, physics, and other disciplines.
Applications will be evaluated by a joint scientific advisory committee of the Head and Neck Cancer Research Team to decide on invitations to the Idea Lab. This committee, led by Hillman and comprising representatives from each of the funding organizations, will select and oversee the chair and the cervical cancer research team.
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Mirabai Vogt James
Stand up to cancer
About standing up to cancer
The Stand Up To Cancer® (SU2C) Foundation is raising funds to accelerate the pace of research to quickly deliver new treatments to patients and save lives now. SU2C, a division of the Entertainment Industry Foundation, a 501 (c) (3) charitable organization, was created in 2008 by media and entertainment leaders who are using the resources of these communities to engage the public in support of a new collaborative model for cancer research, to raise awareness about Cancer prevention, highlighting progress in disease control. As of August 2020, more than 1,950 scientists representing more than 210 institutions are participating in research projects funded by SU2C.
Under the guidance of our Scientific Advisory Committee, led by Nobel Prize Winner Philip A. Sharp, Ph.D., SU2C operates rigorous competitive reviews to identify the best research proposals to recommend funding, oversee grant administration, and ensure collaboration across research programs.
Current members of the SU2C (CFA) Founders and Adviser Council include Katie Couric, Sherry Lansing, Kathleen Loeb, Lisa Poulsen, Rusty Robertson, Sue Schwartz, Pamela Oase Williams, and Ellen Zevrin. The late Laura